New publications from our collaborators

Our AKITA Plate has been featured in the Oncogene paper by Professor Aki Manninen et al. A custom made brain disorder modeling platform was published by Nikita et al in IJMS highlighting the importance of turbulence free neuron culture.

Bone-marrow chip mimics prostate cancer infiltration and drug response

The publication "Disassembly of hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions" demonstrated that simultaneous loss of PTEN and hemidesmosomes induced several tumorigenic properties including proliferation, migration, resistance to anoikis, apoptosis, and drug treatment in vitro, and increased metastatic capacity in vivo by using an extensive CRISPR/Cas9-mediated genetic engineering approaches in different prostate cancer cell lines combined with in vivo tumorigenesis studies in mice, bone marrow-on-chip assays and bioinformatics, as well as histological analysis of prostate cancer patient cohorts. The studies showed that these effects were driven by activation of EGFR/PI3K/Akt and FAK/Src-pathways and were abolished by plectin downregulation. Therefore, dual loss of PTEN and hemidesmosomes may have diagnostic value helping to stratify prostate cancer patients with a high risk for development of aggressive disease and highlight plectin as a potential therapeutic target in prostate cancer.

Bone marrow-on-chip assay analysis of co-culture of Tdtomato-expressing jMC3T3 osteoblasts and GFP-positive PC3 cells treated with DTX (E), representative picture of coculture of MC3T3 osteoblasts and PC3 or PC3 α6-KO cancer cells treated with 1nM DTX 

Microfluidic neurons-on-chips provide an optimal platform for studying mechanosensitive receptors

Data published in IJMS publication "Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model” has shown that turbulence free microfluidic neuron-on-chip clearly differentiates trigeminal versus dorsal root ganglion neural mechanosensitivity.. Finnadvance’s precision microfluidic chip fabrication demonstrated reproducibility of the results.

Turbulence occurring in conventional imaging setup.

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