Faster, cheaper and more accurate is an understatement. We’re helping the world discover new medicine at a faster pace.
We are constantly publishing our results in peer-reviewed journals. Please find the works from our team and collaborators below.
Our lumen-on-chip platform was used in the recent publication in Oncogene by Professor Aki Manninen from Disease Networks at University of Oulu: "Disassembly of hemidesmosomal adhesions promotes tumorigenesis in PTEN-negative prostate cancer by targeting plectin into focal adhesions" (link here: ). With Professor Manninen we demonstrated that simultaneous loss of PTEN and hemidesmosomes induced several tumorigenic properties including proliferation, migration, resistance to anoikis, apoptosis, and drug treatment in vitro, and increased metastatic capacity in vivo by using an extensive CRISPR/Cas9-mediated genetic engineering approaches in different prostate cancer cell lines combined with in vivo tumorigenesis studies in mice, bone marrow-on-chip assays and bioinformatics, as well as histological analysis of prostate cancer patient cohorts. The studies showed that these effects were driven by activation of EGFR/PI3K/Akt and FAK/Src-pathways and were abolished by plectin downregulation. Therefore, dual loss of PTEN and hemidesmosomes may have diagnostic value helping to stratify prostate cancer patients with a high risk for development of aggressive disease and highlight plectin as a potential therapeutic target in prostate cancer.
Data published in MDPI publication "Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model” by Nikita et al at A. I. Virtanen Institute for Molecular Sciences has shown that turbulence free microfluidic neuron-on-chip clearly differentiates trigeminal versus dorsal root ganglion neural mechanosensitivity.. Finnadvance’s precision microfluidic chip fabrication demonstrated reproducibility of the results.
Want to understand how AKITA platform could help you achieve the scientific milestones faster with higher confidence? Below you can download our scientific protocols.
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